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Stainless steel body with side grips for easy carriage with vacuum desiccator and pressure gauze. Front panel with on off switch and timer. Supplied complete with 1.5 m cord and plug to work on 220 - 240 V 50 Hz A.C. mains.

NPH-49 LEAKAGE TEST V

Stainless steel body with side grips for easy carriage with vacuum
desiccator and pressure gauze. Front panel with on off switch and
timer. Supplied complete with 1.5 m cord and plug to work on 220 –
240 V 50 Hz A.C. mains.

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NPH-11 FRIABILITY TEST APPARATUS SINGLE Friability testing is a crucial quality control measure in the pharmaceutical industry, assessing the durability of tablets during packaging, handling, and shipping. This test helps ensure that tablets can withstand mechanical shocks without breaking or crumbling, maintaining their integrity and efficacy. The apparatus used for this test is known as a friabilator or friability test apparatus. The principle of a friability tester involves placing tablets in a rotating drum and measuring the weight loss due to chipping or breaking under friction, pressure, or vibration. The majority of the tests use the Friabilator principle. Why Do Pharmaceuticals Perform a Friability Test? Friability testing is performed to check the strength or durability of tablets. Tablets must be strong enough to resist breakage during transportation, coating & blistering process. Friability test is performed for core or uncoated tablets & not performed for coated tablets. Coating polymers give strength & protection to tablets against breaking thats why the Friability Test not performed for Coated Tablets According to the guidelines, tablets should be tested for friability to ensure they do not lose more than a certain percentage of their weight after a specific number of rotations. Speed and Timer Controls: These allow precise setting of the rotation speed and test duration, ensuring consistency across tests. Modern machines may have digital displays for ease of use. Weighing Balance: A highly accurate balance is required to measure the weight of the tablets before and after the test. The Friability Test Apparatus consists of the following key components: Rotating Drum: Typically made of transparent plastic,Acrylic, with a diameter of about 283-291 mm and a depth of approx.40 mm. The drum has a curved baffle that allows tablets to roll and fall within the drum as it rotates. Rotation Speed: The drum rotates at a speed of 25 ± 1 rpm. 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This ensures that manufacturers can compare their results with industry norms and regulatory requirements. Replicable and Reliable Results: These testers produce consistent and accurate results, allowing manufacturers to evaluate the durability of their tablets and granules under controlled conditions. Fast and Efficient Testing: The Friability Test is a relatively quick process, allowing manufacturers to evaluate the quality of their tablets and granules promptly. This enables manufacturers to identify and address potential issues in their formulation and manufacturing processes. Compliance with Regulatory Guidelines: Friability tests help manufacturers comply with regulatory requirements, ensuring that their products meet the industry’s strict safety and efficacy standards. Early Detection of Issues: The Friability Test can identify potential problems with tablet durability early in the development and manufacturing process. This allows for corrective actions to be taken before large-scale production, minimizing waste and reducing the risk of product failure. Cost-Effective: Friability testers are a relatively affordable investment for manufacturers, providing a cost-effective solution for ensuring the quality and durability of their tablets and granules. Limitations of Friability Testers Limited Scope: Friability testers primarily evaluate the tablet’s ability to withstand mechanical stress during handling and transportation. They do not provide insights into other critical aspects, such as the tablet’s disintegration, dissolution, or drug release properties. Not Suitable for All Tablet Types: Friability tests may not be suitable for all types of tablets, such as coated or enteric-coated tablets. These tablets may require alternative testing methods to properly assess their durability and performance. 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Regular maintenance and calibration further enhance the reliability of the test, contributing to the overall quality assurance process in tablet manufacturing.
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